Project Collaboration
Methodological and analytical support for clinical research, from the first draft of a proposal through to publication.
SCRI's HEOR and Biostatistics teams partner with investigators throughout the research journey. Combining expertise in epidemiology, health economics, outcomes research, biostatistics, and evidence synthesis, we help develop robust study designs, analytical plans, and evaluation frameworks that meet the expectations of funders, reviewers, and regulators. Together, we support the generation of high-quality evidence that advances clinical practice and healthcare decision-making.
Study design and protocol methodology
Contributing to the methodology sections of the protocol: the study design, and the statistical analysis and economic evaluation plan, including sample size. This extends to reviewing the protocol through its amendments.
Data collection and database design review
Reviewing data collection forms and database design, in printed or electronic form, before data collection starts.
Analysis plan development
A full analysis plan, including mock shells for the planned tables, figures and listings, so that what will be produced is agreed before any analysis begins.
Data review
Preparing specifications and mock shells, then generating tables, figures and listings for review of the collected data, so that quality issues surface while there is still time to act on them.
Analysis dataset development
Developing dataset specifications and building and validating the derived datasets the analysis will run on.
Statistical analysis and programming
Carrying out the analysis as specified in the analysis plan.
Secondary analysis of existing data
Planning and conducting analyses of data already collected, whether from a completed study, a disease registry, a cohort, or administrative sources, through to a manuscript.
Areas of support
What a study needs after award depends on the study type. Each section below covers one type, from the statistics behind a clinical trial to the economics of an adoption decision.
Clinical Trials
We design and size trials of any phase, generate the randomisation, review the case report forms and database before data collection begins, write the statistical analysis plan, support the data monitoring committee, and carry out the interim and final analyses.
Health outcomes research
We design and analyse studies of what actually changes for patients when a service or programme is delivered, including clinical and patient-reported outcomes and primary observational studies.
Real-world evidence
We work with data already generated by care as it is delivered — health records, disease registries and administrative sources — preparing and linking it, and putting new questions to data already collected.
Health economic evaluation
We design and carry out economic evaluations alongside a clinical study or on their own — cost-effectiveness, cost-utility and budget impact analysis.
Systematic review and meta-analysis
We contribute to developing the search strategy, assessing risk of bias and running the synthesis. Screening, selection and extraction stay with your team, with our advice.
Health technology assessment
We support the assessment that stands between evidence and a decision to adopt: the assessment question and methodology, the evidence an adoption decision needs, and the report itself.
Reporting and publication
Analysis is only useful once it has been communicated. Whichever kind of study you are running, we stay involved through the write-up.
Statistical analysis reports
Preparing a report that sets out the study methodology and findings. For trials this includes the interim reports prepared for the data monitoring committee as well as the final report.
Study report support
Reviewing and supporting the write-up of the final study report, including the statistical methods and results sections of a clinical study report.
Manuscript, abstract and poster support
Reviewing the full manuscript and supporting the writing of the methods and results sections, including help in responding to reviewers’ comments on the analysis.
Where a member of our team contributes to a manuscript, poster, abstract or presentation, they are credited with co-authorship in accordance with the ICMJE authorship guidelines (opens in new tab).
Tailored support
Not every project calls for the full scope of collaboration. If you need support for specific components of your project only, we can accommodate that — whether it is literature searching, systematic review, study design, sample size estimation, randomisation, analysis of health outcome data, health economic evaluation, or reporting and manuscript writing.
Engaging us
The earlier we are involved, the more we can help. Decisions about design, data collection and analysis are made at the start of a study, and they determine what the data will be able to tell you at the end.
To discuss a project, contact us via email: contact@scri.cris.sg
Related pages: Grant Application Collaboration · Consultancy Services