AHCC07

AHCC 07	Precision Medicine in Liver Cancer across an Asia-Pacific Network (The PLANet Study) (NCT03267641)
Status	Updated data as of June 2025 showed that 187 of 277 patients have reached the study end-points (as defined by recurrence or death, or completion of 3 years follow-up from date of surgery). Two main publications in Cell (DOI: 10.1016/j.cell.2020.08.040) and Nature Communications (DOI: 10.1038/s41467-020-20171-7). Patent: A system and method for classifying cancer patients into appropriate cancer treatment groups and compounds for treating the patient (Valerie Chew, Pierce Chow, Albani Salvatore) (Application number: 10201709924T; Filing Date: 30/11/2017) Cell-based biomarkers of immunotherapy in hepatocellular carcinoma (Ankur Sharma, Florent Ginhoux, Ramanuj Dasgupta, Pierce Chow) (Singapore Provisional Application number.: 10202007868Q; Filing Date: 17/08/2020)
Contributing Principal Investigators and Centres	Malaysia Yoong Boon Koon (University Malaya Medical Center) Philippines Maria Vanessa H. de Villa (The Medical City) Singapore Pierce Chow (National Cancer Centre), Glenn Bonney (National University Hospital), Brian Goh (Singapore General Hospital) Thailand Rawisak Chanwat (National Cancer Institute) United States of America Sabino Zani Jr (Duke University School of Medicine)
Thematic Principal Investigators	Theme: Genomic evolution in HCC and the discovery of novel drug targets Name: Zhai Weiwei Designation: Senior Research Scientist Institution: Genome Institute of Singapore Theme: Translational Immunomics: Immune-phenotyping, monitoring and discovery of novel immunotherapies Name: Salvatore Albani Designation: Director Institution: SingHealth Translational Immunology and Inflammation Centre Theme: Clinical Trajectory and Translational Therapeutics Name: Pierce Chow Designation: Senior Consultant Institution: National Cancer Centre
Protocol Chair	Pierce Chow pierce.chow@duke-nus.edu.sg