Infectious Diseases and Immunology

SCRI has extensive and growing experience with infectious disease and immunology studies

Vancomycin versus daptomycin for the treatment of methicillin-resistant Staphylococcus aureus bacteremia due to isolates with high vancomycin minimum inhibitory concentrations: study protocol for a phase IIB randomized controlled trial.

Kalimuddin S, Phillips R, Gandhi M, de Souza NN, Low JG, Archuleta S, Lye D, Tan TT. Trials 2014, 15:233.

Chlorhexidine’s role in skin antisepsis: questioning the evidence

Maiwald M, Assam PN, Chan ESY, Dancer SJ. Lancet 2014; 384(9951): 1344-1345

Safety and immunogenicity of a virus-like particle pandemic influenza A (H1N1) 2009 vaccine: results from a double-blinded, randomized Phase I clinical trial in healthy Asian volunteers

Low JG, Lee LS, Ooi EE, Ethirajulu K, Yeo P, Matter A, Connolly JE, Skibinski DA, Saudan P, Bachmann M, Hanson BJ, Lu Q, Maurer-Stroh S, Lim S, Novotny-Diermayr V. Vaccine 2014, 32: 5041-5048.

Patients’ preference and health utility assesments in HCV patients treated with sofosbuvir regimens: stating the obvious?

Lim SG, Gandhi M, Chan ESY. Alimen Pharmacology & Therapeutics 2014, 40(9): 1115.

Efficacy and safety of celgosivir, an alpha-glucosidase inhibitor, in dengue fever patients evaluated in a randomized, double blind, placebo controlled proof-of-concept clincal trial

Low JG*, Sung C*, Wijaya L*, Wei Y, Rathore APS, Watanabe S, Tan BH, Toh L, Chua LT, Hou Y, Chow A, Howe S, Chan WK, Tan KH, Chung JS, Cherng BP, Lye DC, Tambayah PA, Ng LC, Connolly J, Hibberd ML, Leo YS, Cheung YB, Ooi EE, Vasudevan SG Lancet Infectious Diseases 2014, 14(8): 706-715.

Bacterial contamination of surgical scrub suits worn outside the operating theatre: a randomised crossover study

Hee HI, Lee S, Chia SN, Lu Q, Liew APQ and Ng A. Anaesthesia 2014, 69(8):816 - 825.

Pitfalls in evidence assessment: the case of chlorhexidine and alcohol in skin antisepsis

Maiwald M, Chan ES. J Antimicrob Chemother. 2014;69(8):2017-21.

Molecular analysis of infant fecal microbiota in an Asian at-risk cohort–correlates with infant and childhood eczema

Yap GC, Loo EXL, Aw M, Lu Q, Shek LPC and Lee BW. BMC Research Notes 2014, 7:166.

Probiotic supplementation in the first 6 months of life in at-risk Asian infants – Follow-up till 5 years

Loo E, Lianora GV, Lu QS, Aw M, Lee BW, Shek LP. International Archives of Allergy and Immunology 2014,163(1):25-28.

Oral versus intravenous antibiotics for patients with Klebsiella pneumoniae liver abscess: study protocol for a randomised controlled trial

Molton JS, Phillips R, Gandhi M, Yoong J, Lye D, Tan TT et al. Trials 2013, 14:364.

Use of statistics as another factor leading to overestimation of chlorhexidine’s role in skin antisepsis

Maiwald M, Petney T, Assam PN, Chan ES. Infect Control Hosp Epidemiol 2013;34(8):872-3.

Hyperbaric oxygen therapy in necrotising soft tissue infections: a study of patients in the United States Nationwide Inpatient Sample

Soh CR, Pietrobon R, Freiberger JJ, Chew ST, Rajgor D, Gandhi M, Shah J, Moon RE. Intensive Care Med. 2012;38(7):1143-51.

Estimation and interpretation of incidence rate difference for recurrent events when the estimation model is misspecified

Xu Y, Cheung YB, Lam KF, Milligan P. Biom J. 2012;54(6):750-65.

Estimation of summary protective efficacy using a frailty mixture model for recurrent event time data

Xu Y, Cheung YB, Lam KF, Tan SH, Milligan P. Stat Med. 2012;31(29):4023-39.

The Effect of Monthly Sulfadoxine-Pyrimethamine, Alone or with Azithromycin, on PCR-Diagnosed Malaria at Delivery: A Randomized Controlled Trial

Luntamo M, Rantala A-M, Meshnick SR, Cheung YB, Kulmala T, Maleta K, et al. PLoS ONE 7(7): e41123.

Evaluation of stool microbiota signatures in two cohorts of Asian (Singapore and Indonesia) newborns at risk of atopy

Yap GC, Chee KK, Hong P-Y, Lay C, Satria C, Sumadiono, Soenarto Y, Haksari EL, Aw M, Shek P-C, Chua KY, Zhao YD, Leow D. and Lee BW. BMC Microbiology. 2011, 11:193.

Domains of health-related quality of life important and relevant to multiethnic English-speaking Asian systemic lupus erythematosus patients: a focus group study

Ow YLM, Thumboo J, Cella D, Cheung YB, Fong KY, Lim YT, Sow WT, Wee HL. Arthritis Care Res (Hoboken). 2011 Jun;63(6):899-908.

The Early Clinical Features of Dengue in Adults: Challenges for Early Clinical Diagnosis

Low JGH, Ong A, Tan LK, Chaterji S, Chow A, Lim WY, Lee KW, Chua R, Chua CR, Tan SWS, Cheung YB, Hibberd ML, Vasudevan SG, Ng LC, Leo YS, Ooi EE. PLoS Neglected Tropical Diseases, 2011;5(5):e1191. Epub.

Serotype-specific avidity is achieved following a single dose of the 7-valent pneumococcal conjugate vaccine, and is enhanced by 23-valent pneumococcal polysaccharide booster at 12 months

Russell FM, Balloch A, Licciardi PV, Carapetis JR, Tikoduadua L, Waqatakirewa L, Cheung YB, Mulholland EK, Tang MLK. Vaccine. 2011;29(27):4499-506

Chloroquine for influenza prevention: a randomised, double-blind, placebo controlled trial

Paton N, Lee L, Xu Y, Ooi EE, Cheung YB, Archuleta S, Wong G, Wilder-Smith A. Lancet Infect Dis. 2011;11(9):677-83.

Opsonophagocytic activity following a reduced dose 7-valent pneumococcal conjugate vaccine infant primary series and 23-valent pneumococcal polysaccharide vaccine at 12 months of age

Russell FM, Carapetis JR, Burton RL, Lin J, Licciardi PV, Balloch A, Tikoduadua L, Waqatakirewa L, Cheung YB, Tang ML, Nahm MH, Mulholland EK. Vaccine. 2011;29(3):535-44.

Lack of association of dengue activity with haze

Wilder-Smith A, Earnest A, Tan SB, Ooi EE, Gubler D. Epidemiology and Infection. 2010;138(7):962-7.

Hyporesponsiveness to re-challenge dose following pneumococcal polysaccharide vaccine at 12 months of age, a randomized controlled trial

F.M.Russell, J.R.Carapetis, A.Balloch, P.V.Licciardi, A.W.J.Jenney, L.Tikoduadua, L.Waqatakirewa, J.Pryor, J.Nelson, G.B.Byrnes, Y.B.Cheung, M.L.K.Tang, E.K.Mulholland. Vaccine. 2010;28(19):3341-9.

Safety and immunogenicity of the 23-valent pneumococcal polysaccharide vaccine at 12 months of age, following one, two, or threes doses of the 7-valent pneumococcal conjugate vaccine in infancy

Russell FM, Licciardi PV, Balloch A, Biaukula V, Tikoduadua L, Carapetis JR, Nelson J, Jenney AW, Waqatakirewa L, Colquhoun S, Cheung YB, Tang ML, Mulholland EK. Vaccine. 2010;28(18):3086-94.

Immunogenicity following one, two, or three doses of the 7-valent pneumococcal conjugate vaccine

Russell FM, Balloch A, Tang MLK, Carapetis JR, Licciardi P, Nelson J, Jenney AWJ, Tikoduadua L, Waqatakirewa L, Pryor J, Byrnes GB, Cheung YB, Mulholland EK. Vaccine. 2009;27(41):5685-91.

Nasopharyngeal carriage of streptococcus pneumoniae in Gambian children who participated in a 9-valent pneumococcal conjugate vaccine trial and in their younger siblings

Cheung YB, Zama SMA, Nsekpong ED, et al. Pediatr Infect Dis J. 2009; 28:990-995.

Role of procalcitonin in infectious gastroenteritis and inflammatory bowel disease

Thia TJK, Chan ESY, Ling KL, Ng WY, Jacob E, Ooi CJ. Dig Dis Sci. 2008;53(11):2960-8.