PLANet 2.0 – AHCC12 and AHCC13

AHCC12 & AHCC13

Precision Medicine in Liver Cancer across an Asia Pacific Network 2.0 (PLANet 2.0)

AHCC12:

Deep, Multi-omics Phenotyping to Predict Response, Resistance and Recurrence to Adjuvant Atezolizumab plus Bevacizumab in Resected Hepatocellular Carcinoma (HCC)(EMPHASIS)(NCT05516628)

AHCC13:

Liquid Biopsy based Identification of Predictive Biomarkers of Response in Intermediate/Locally Advanced HCC receiving Y90 +/- Atezolizumab plus Bevacizumab (NCT05377034)
Status

Planned recruitment to start by the end of Q3 2022
Contributing Principal Investigators and Centres

Singapore

Adrian Chiow (Changi General Hospital), Toh Han Chong (National Cancer Centre), Chee Cheng Ean (National University Hospital), Kam Juinn Huar (Sengkang General Hospital), Brian Goh (Singapore General Hospital), samol jens (Tan Tock Seng Hospital)

Up to 11 overseas sites in Asia-Pacific
Thematic Principal Investigators

Theme 1: Deep Phenotyping and Correlation with Clinical Responses to Therapy

Name: Pierce Chow
Designation: Senior Consultant
Institution: National Cancer Centre

Name: Patrick Tan
Designation: Executive Director
Institution: A*STAR Genome Institute of Singapore

Theme 2: Elucidating Spatial Distribution of Biomarkers at Single-cell Resolution

Name: Vinay Tergaonkar
Designation: Research Director
Institution: A*STAR Institute of Molecular and Cell Biology

Theme 3: Translational and Functional Immunomics

Name: Toh Han Chong
Designation: Senior Consultant
Institution: Division of Medical Oncology, National Cancer Centre

Theme 4: Pre-Clinical Disease Modelling and Target Discovery

Name: Tam Wai Leong
Designation: Senior Research Scientist
Institution: A*STAR Genome Institute of Singapore

Name: Edward Chow
Designation: Associate Director and Principal Investigator
Institution: Cancer Science Institute

Theme 5: Data Architecture, Data Security and Data Science Applications

Name: Roger Vaughan
Designation: Director
Institution: Centre for Quantitative Medicine, Duke-NUS Medical School
Protocol Chair

Pierce Chow
pierce.chow@duke-nus.edu.sg