Singapore Clinical Research Institute (SCRI)

SCRI currently manages over 30 studies including investigator-initiated academic trials, single and multiple-site studies, and multi-national-site studies.  Research areas include epidemiology, dentistry, nutrition, psychiatry, surgery and paediatrics. Specific disease areas include oncology, ophthalmology, cardiology, nephrology and neurology.

Oncology 

• Aspirin for stage III and high risk stage II colorectal cancer
• Placebo versus appetite enhancing medication for inoperable liver cancer
• A study to evaluate efficacy of radioactive iodine as adjuvant therapy for liver cancer post surgery v/s conventional follow-up treatment (no adjuvant therapy after surgery)
• Phase I/II study of radiotherapy plus multi-kinase inhibtor as first line treatment in patients with non-resectable primary liver cancer
• Frequent but low dose of combined treatment regime ( dexamethasone, thalidomide & zmeta ) for multiple myeloma
• A study comparing two non-steroid based anti-inflammatory drugs for the treatment of a heart problem involving abnormal blood flow in very premature infants.
• Effects of (monoclonal) antibody in combination with chemotherapy and radiotherapy for head and neck cancer treatment
• Evidence-synthesis and modelling of hepatocellular cancer clinical management data for improving patient outcomes and health services planning.
• A study to compare the impact of high dose radiation therapy (through radiotherapy devices) to an anti-cancer drug for overall survival in patients with advanced liver cancer.
• Assessing the effects of an immunosuppressant in combination with a (monoclonal) antibody for the treatment of advanced liver cancer
• An evaluation of a combination treatment composed of three chemotherapeutic agents and an anti-viral protein in liver cancer.

Ophthalmology

• A prophylactic laser vs. no treatment in subject with asymptomatic narrow angles.
• A study to compare 2 treatments: laser and surgery in glucoma
• To establish an optimal dose of atropine, for routine myopia treatment in children
   

Cardiology

• Comparison of vasopressin and adrenaline injections for cardiac arrest
• Comparing the capacity of high versus low energy defibrillation (shock) in patients with heart attack
• To compare the incidence of adverse cardiac events among patients discharged after evaluation through ACTION (acute chest pain treatment and evaluation) and control group

Nephrology

• Effectiveness of antibody for prevention of rejection in kidney transplant patients (pilot study)
• Effectiveness of antibody for prevention of rejection in kidney transplant patients (phase II study)
• A preventive treatment regime in cardiac catherisation subjects to reduce to side effects of contrast.

Nutrition 

• Study extension on child's allergic incidence till 5 years old, who receive milk with or without probiotics for the first 6 months 
• A follow-up to 5 years study two groups of children will be compared with one group of children fed beneficial bacteria and the other without to see the beneficial bacteria's influence on allergic disease.
   

Neurology 

• To test that clopidogrel in addition to aspirin is superior to aspirin alone in treating patients with stroke
• Chinese medicine neuroaid efficacy on stroke recovery
• Establishing a practical and theoretical foundation for comprehensive and integrated community, policy and academic efforts to improve dementia care in

Psychiatry

• Thyroid and depression
• Pregnenolone to improve cognitive functioning for schizophrenia patient
• A comparative study, ethnic differences in depression will be studied among Asians and Caucasians

Surgery

• Optimization of surgery timing and techniques for cleft palate treatment

Epidemiology Studies

• An observational study to identify the factors that predict conversion to psychosis in young persons age 14 - 29 years
• An observational study to document incidence of allergies and evaluate stool microbiota between babies from Singapore & Indonesia
• An observational study evaluating effect of breastmilk & dietary fatty acid on allergy in babies
• A review of guidelines for looking at the role of ‘body's protective system (immunology) in a nerve disorder (Multiple Sclerosis). This review is conducted every three years (Triennial) by ‘American' Academy of Neurology (AAN)

Paediatrics

• Used of antibiotic in reducing incidence of chronic lung disease in infant who chronized with bacteria and low birth weight

Orthopaedics 

• A study on patients requiring knee joint cartilage repair will be implanted with a transplant system derived from the same affected patient's body(cells) in comparison to the conventional method

Infectious Disease

• A study to determine the efficacy of Chloroquine (anti-malarial drug) in the prevention of influenza
• A study aims to compare two dengue fever patient groups with reduced platelet counts and without bleeding; one with supportive care and platelet transfusion and the other with just supportive care to determine the benefits of platelet transfusion.
• Vaccine development against Influenza (flu) (subtype A)