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Singapore Clinical Research Institute (SCRI)

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Home Clinical Trials

Clinical Trials

AHCC protocol 06 Phase III Multi-Centre Open-Label
Randomized Controlled Trial of Selective
Internal Radiation Therapy (SIRT) Versus
Sorafenib in Locally Advanced Hepatocellular
Carcinoma.
Status Recruiting from July 2010. Planned sample size of 360 patients.

Contributing Principal Investigators and Centres

Brunei
Kenneth Kok (Raja Isteri Pengiran Anak Saleha Hospital)

Hong Kong
Ronnie Poon (Queen Mary Hospital),

Indonesia
L.A Lesmana (Cipto Mangunkusumo Hospital, University of Indonesia),
Tjakra Wibawa Manuaba (Denpasar General Hospital, Bali)

Korea
Hyun-Ki Yoon (Asan Medical Center),
Yun-Hwan Kim (Korea University Anam Hospital),
Ho-Seong Han (Seoul National University Bundang Hospital),
Si-Hyun Bae (Seoul St Mary's Hospital),     
Jong-Yun Won(Severance Hospital, Yonsei University),           
Jin-Mo Yang (St Vincent's Hospital)
 
Malaysia
Aloysius Raj (Penang Adventist Hospital)

Mongolia
Ariunaa Khasbazar (National Cancer Center of Mongolia)

Myanmar
Khin Maung Win (Yangon GI & Liver Centre)

New Zealand
Adam Bartlett (Auckland City Hospital)

Philippines
Rolley Lobo (Davao Doctors Hospital),
Catherine Teh (Makati Medical Center),
Janus Ong (The Medical City),
Ian Cua (St Luke's Medical Center)

Singapore
Jessica Tan (Changi General Hospital),
Jude Lee (Khoo Teck Puat Hospital),
Choo Su Pin (National Cancer Centre of Singapore),
Stephen Chang (National University Hospital),
Cheow Peng Chung (Singapore General Hospital)

Taiwan
Chien-Fu Hung (Chang Gung Memorial Hospital),
Po-Chin Liang (National Taiwan University Hospital),
Rheun-Chuan Lee (Taipei Veterans General Hospital)
Protocol Chair Pierce Chow
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AHCC protocol 05
Phase I/II Study of SIR-Spheres plus Sorafenib (Chemo-Radiotherapy) as first line treatment in patients with non-resectable primary hepatocellular carcinoma.
Status
Completed in June 2009 with recruitment of 35 patients. Manuscript in progress.
Contributing Principal Investigators and Centres
Pierce Chow (SGH, Singapore), Anthony Goh (SGH, Singapore), Soo Khee Chee (NCC, Singapore), Tan Say Beng (SCRI, Singapore), Alexander Chung (SGH, Singapore), Lai Hee Kit (SGH, Singapore), Tay Kiang Hiong (SGH, Singapore), Richard Hoau Gong Lo (SGH, Singapore), Donald Poon Yee Hee (NCC, Singapore), Choo Pin (NCC, Singapore), Han Ho Seong (Seoul, Korea), Harjit Singh (Selayang, Malaysia), Khin Maung Win (Yangon, Myanmar)
Protocol Chair Pierce Chow
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AHCC protocol 04
Dose escalating trial of intra-tumoral BrachySil in unresectable hepatocellular carcinoma.
Status Closed. Results Published in International Journal of Radiation Oncology *Biology*Physics  Vol. 67, Issue 3, 1 March 2007; 786-792
Contributing Principal Investigators and Centres
Pierce Chow (SGH, Singapore), Anthony Goh (SGH, Singapore), Richard Guan (Mt Elizabeth Hospital, Singapore) Foo Kian Fong, Susan Loong (NCC, Singapore), Liau Kui Hin (TTSH, Singapore), Hoang Hoa Hai (Choray Hospital, Ho Chi Min City), Harjit Singh (Selayang Hospital, Kuala Lumpur)
Protocol Chair Pierce Chow
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AHCC protocol 03
Randomised trial of adjuvant intra-arterial radio-active iodine after curative resection of hepatocellular carcinoma.
Status Completed in March 2007 with recruitment of 103 patients. Manuscript Submission in progress.
Contributing Principal Investigators and Centres
Pierce Chow (SGH, Singapore), Lucien Ooi (NCC, Singapore), Tay Khoon Hean (Changi General Hospital, Singapore), Chew Soo Ping (Tan Tock Seng Hospital, Singapore)
Protocol Chair Alexander Chung
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AHCC protocol 02
Randomised trial of megestrol acetate versus placebo in the treatment of inoperable hepatocellular carcinoma.
Status Completed in 2007 with recruitment of 204 patients. Results published in Br J Cancer. 2011 September 27; 105(7): 945–952.
Contributing Principal Investigators and Centres
Pierce Chow, Khin Maung Win (Myanmar), Soo Khee Chee (Singapore), Hoang Hoa Hai (Ho Chi Min City, Vietnam), Nguyen Ba Duc (Hanoi, Vietnam), Jin Mo-Yang (South Korea), R Lobo (Phillipines), M Findlay (New Zealand)
Protocol Chair Pierce Chow
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AHCC protocol 01
Randomised trial of high-dose tamoxifen versus placebo in the treatment of inoperable hepatocellular carcinoma.
Status
Completed in June 2000 with recruitment of 324 patients. Results published in Hepatology 2002 36:1221-1226
Contributing Principal Investigators and Centres
Pierce Chow(Singapore), Khin Maung Win (Myanmar), Phillip Johnson (Hong Kong), Soo Khee Chee (Singapore), Tan Chee Kiat (Singapore), T Manuaba (Indonesia), Thiravud Khuhaprema (Thailand), A Haron (Malaysia), SH Bae (South Korea), J Cebon (Australia), M Findlay (New Zealand)
Protocol Chair Pierce Chow
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