5. Singapore Infectious Diseases Clinical Research Network (SCRN)

Clinical Research Networks in Singapore Contacts

Singapore Infectious Diseases Clinical Research Network (SCRN) is funded by the Ministry of Health, Singapore through Singapore Infectious Diseases Initiative and hosted by Tan Tock Seng Hospital. The network aims to engage local infectious diseases clinicians in a collaborative approach to spearhead cross-institutional clinical trials in Singapore.

Currently, the network assists in the coordination of 3 multi-center clinical trials and 1 clinical study in various tertiary-setting hospitals, including Tan Tock Seng Hospital, National University Hospital, and Singapore General Hospital. The 3 clinical trials involve comparing the efficacy of:

  • Early step-down to oral antibiotics versus intravenous antibiotics in patients with Klebsiella pneumonialiver abscess (AKLASS);
  • Vancomycin versus daptomycin for the treatment of methicillin-resistantStaphylococcus aureusbacteremia (MRSA); and
  • Combinational antibiotics treatment (Polymyxin B and doripenem) versus single antibiotics treatment (only Polymyxin B) for serious infections caused by extensively drug-resistant Gram-negative bacteria (XDR-GNB).

The clinical study involves defining the local epidemiology of carbapenem-resistant Enterobacteriaceae (CRE) and the associated mortality and morbidity (CaPES).

Dr Ding Ying
Network Coordinator
Email: ying_ding@ttsh.com.sg