Singapore Clinical Research Institute (SCRI)

Edwin Chan Shih Yen BVMS(Hons), PhD
Head, Epidemiology

 Other affiliations:
Assistant Professor, Duke-NUS Graduate Medical School, Singapore

E-Mail:  This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Web: www.scri.edu.sg

Research Interests:

• Systematic review methodology for intervention, diagnostic and observational studies
• Critical appraisal methods for clinical research literature
• Clinical decision-making involving diagnostic and screening test strategies

Selected Publications:

Chan SY, Ho L, Ong CK, Chow V, Drescher B, Durst M, ter Meulen J, Villa L, Luande J, Mgaya HN, Bernard HU. Molecular variants of human papillomavirus type 16 from four continents suggest ancient pandemic spread of the virus and its coevolution with humankind. J Virol 1992; 66: 2057-66.

Balaram P, Nalinakumari KR, Abraham E, Balan A, Hareedran NK, Bernard HU, Chan SY. Human papillomaviruses in 91 oral cancers from Indian betel quid chewers - high prevalence  and multiplicity of infections. Int  J Cancer 1995; 61: 450-54.

Chan SY, Delius H, Halpern A, Bernard HU. Analysis of genomic sequences of 95 papillomavirus types - uniting typing, phylogeny and taxonomy.  J Virol 1995; 69: 3074-83.

Chan ESY. Meta-analyses of Clinical Drug Trials - Gold Standard Reviews or Statistical Alchemy? Ann Acad Med Singapore 2000; 29: 610-15.

Saw SM, Chan ESY, Koh A, Tan D. Interventions to retard myopia progression in children: An evidence-based update. Ophthalmology 2002; 109: 415-421.

Luman W, Chan ESY. Mathematical model for predicting biliary therapeutic endoscopic retrograde pancreatography (ERCP). Digestive and Liver Disease 2003; 35:486-492.

Wai CT, Cheng CL, Wee A, Dan Y-Y, Chan ESY, Chua W, Mak B, Oo AM, Lim SG. Non-invasive models for predicting histology in patients with chronic hepatitis B. Liver International 2006; 26: 666-672.

Ng SC, Liao ZT, Tak DTY, Chan ESY, Zhao LK, Gu JR. Epidemiology of spondyloarthritis in the People’s Republic of China: Review of the literature and commentary.  Seminars in Arthritis and Rheumatism 2007; 37:39-47.

Goh SK,  Samuel M, Su DHC, Chan ESY, Yeo SJ. Meta-analysis comparing total hip arthroplasty with hemiarthroplasty in the treatment of displaced neck of fémur fracture. J Arthroplasty 2008; (Epub ahead of print Aug 11).

Chen C, Venketasubramaniam V, Gan RN, Lambert C, Picard D, Chan BPL, Chan ESY, Bousser MG, Shi X. Danqi Piantang Jiaonang (DJ), a traditional Chinese Medicine in post-stroke recovery. Stroke 2009; (online Jan 22).