Completed Trials

AHCC 06

Phase III Multi-Centre Open-Label Randomized Controlled Trial of Selective Internal Radiation Therapy (SIRT) Versus Sorafenib in Locally Advanced Hepatocellular Carcinoma (NCT01135056) 

Status

Complete Recruitment; planned sample size of 360 patients. Results were presented at 2017 ASCO Annual Meeting on 4 June 2017. Planning. Publication.

Contributing Principal
Investigators and Centres

Brunei 
Kenneth Kok (The Brunei Cancer Centre)

Hong Kong 
Ronnie Poon (Queen Mary Hospital)

Indonesia 
L.A Lesmana (Cipto Mangunkusumo Hospital, University of Indonesia) Tjakra Wibawa Manuaba (Sanglah General Hospital, Denpasar)

South Korea 
Hyun-Ki Yoon (Asan Medical Center) Yun-Hwan Kim (Korea University Anam Hospital) Ho-Seong Han (Seoul National University Bundang Hospital) Si-Hyun Bae (Seoul St Mary’s Hospital) Jong Yun Won (Severance Hospital, Yonsei University) Jin-Mo Yang (St Vincent’s Hospital)

Malaysia 
Aloysius Raj (Penang Adventist Hospital) James Law Chiong Soon (Sarawak Hospital) Yoong Boon Koon (University Malaya Medical Center)

Mongolia 
Ariunaa Khasbazar (National Cancer Center of Mongolia)

Myanmar 
Khin Maung Win (Yangon GI & Liver Centre)

New Zealand 
Adam Bartlett (Auckland City Hospital)

Philippines 
Rolley Lobo (Davao Doctors Hospital) Catherine Teh (Makati Medical Center) Janus Ong (The Medical City) Ian Cua (St Luke’s Medical Center)

Singapore 
Jessica Tan (Changi General Hospital) Tan Tzu Jen (Khoo Teck Puat Hospital) Choo Su Pin (National Cancer Centre Singapore) Stephen Chang (National University Hospital) Cheow Peng Chung (Singapore General Hospital)

Taiwan 
Chien-Fu Hung (Chang Gung Memorial Hospital) Chao-Long Chen (Chang Gung Memorial Hospital, Kaohsiung) Cheng-Yuan Peng (China Medical University Hospital) Po-Chin Liang (National Taiwan University Hospital)  Rheun-Chuan Lee (Taipei Veterans General Hospital)

Thailand 
Chanisa Chotipanich (Chulabhorn Hospital)

Protocol Chair

Pierce Chow 
pierce.chow.k.h@singhealth.com.sg

AHCC 05

Phase I/II Study of SIR-Spheres plus Sorafenib (Chemo-Radiotherapy) as First Line Treatment in Patients with Non-Resectable Primary Hepatocellular Carcinoma

Status

Completed in June 2009 with recruitment of 35 patients. Published in PLoS ONE 2014 9(3):e90909. doi: 10.1371/journal.pone.0090909.

Contributing Principal
Investigators and Centres
Pierce Chow (SGH, Singapore), Anthony Goh (SGH, Singapore), Soo Khee Chee (NCC, Singapore), Tan Say Beng (SCRI, Singapore), Alexander Chung (SGH, Singapore), Lai Hee Kit (SGH, Singapore), Tay Kiang Hiong (SGH, Singapore), Richard Lo Hoau Gong (SGH, Singapore), Donald Poon Yee Hee (NCC, Singapore), Choo Su Pin (NCC, Singapore), Han Ho Seong (Seoul, Korea), Harjit Singh (Selayang, Malaysia), Khin Maung Win (Yangon, Myanmar)
Protocol Chair

Pierce Chow 
pierce.chow.k.h@sgh.com.sg

AHCC 04 Phase II Dose Escalating Trial of Intra-Tumoral BrachySil in Unresectable Hepatocellular Carcinoma
Status

Completed. Results Published in International Journal of Radiation Oncology *Biology* Physics Vol. 67, Issue 3, 1 March 2007; 786-792.

Contributing Principal Investigators and Centres

Pierce Chow (SGH, Singapore), Anthony Goh (SGH, Singapore), Richard Guan (Mt Elizabeth Hospital, Singapore), Foo Kian Fong, Susan Loong (NCC, Singapore), Liau Kui Hin (TTSH, Singapore), Hoang Hoa Hai (Choray Hospital, Ho Chi Minh City), Harjit Singh (Selayang Hospital, Kuala Lumpur)

Protocol Chair Pierce Chow 
pierce.chow.k.h@sgh.com.sg
AHCC 03 Randomised Trial of Adjuvant Intra-Arterial Radio-Active Iodine after Curative Resection of Hepatocellular Carcinoma
Status

Completed in March 2007 with recruitment of 103 patients. Published inWorld J Surg 6 March 2013: 1-6.

Contributing Principal Investigators and Centres

Pierce Chow (SGH, Singapore), Lucien Ooi (NCC, Singapore), Tay Khoon Hean (CGH, Singapore), Chew Soo Ping (TTSH, Singapore)

Protocol Chair London Ooi
dsoopj@nccs.com.sg
AHCC 02

Randomized Double Blind Trial of Megestrol Acetate Versus Placebo for the Treatment of Inoperable Hepatocellular Carcinoma

Status

Completed in 2007 with recruitment of 204 patients. Results published in Br J Cancer 2011 September 27;105(7): 945–952. 

Contributing Principal Investigators and Centres

Pierce Chow (SGH, Singapore), Khin Maung Win (Yangon, Myanmar), Soo Khee Chee (NCC, Singapore), Hoang Hoa Hai (Ho Chi Minh City, Vietnam), Nguyen Ba Duc (Hanoi, Vietnam), Jin Mo-Yang (Suwon, Korea), Rolley Lobo (Davao City, Philippines), M Findlay (Auckland, New Zealand)

Protocol Chair Pierce Chow 
pierce.chow.k.h@sgh.com.sg
AHCC 01

Randomised Trial of Tamoxifen Versus Placebo for the Treatment of Inoperable Hepatocellular Carcinoma

Status

Completed in June 2000 with recruitment of 324 patients. Results published in Hepatology 2002 36:1221-1226.

Contributing Principal Investigators and Centres

Pierce Chow (SGH, Singapore), Khin Maung Win (Yangon, Myanmar), Phillip Johnson (Shatin, Hong Kong), Soo Khee Chee (NCC, Singapore), Tan Chee Kiat (Singapore), T Manuaba (Denpasar, Indonesia), Thiravud Khuhaprema (Thailand), A Haron (Bangi, Malaysia), Si-Hyun Bae (Korea), J Cebon (Australia), M Findlay (Wellington, New Zealand)

Protocol Chair Pierce Chow 
pierce.chow.k.h@sgh.com.sg